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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could cause a rise in methadone plasma concentrations, which could trigger likely deadly respiratory despair. On top of that, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also lead to an increase in meth